CASE REPORT: SEQUENTIAL COMBINATION TARGETED THERAPY WITH TYPE I AND II MET INHIBITORS IN A METASTATIC EGFR-MUTATED, MET-AMPLIFIED NSCLC PATIENT WITH ACQUIRED MET Y1230H MUTATION

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care for advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results BEETROOT JUICE i

Background.Usage of biosciences in increasing fish production needs to have a proper understanding and knowledge of endocrine physiology of fish reproduction.The most suitable method of determining the reproductive cycle in fishes is to observe seasonal development changes in the gonads.The present paper describes morphological changes in gonads of

This article considers the position of the Gaelic language in the new political context in Scotland created by the opening of the Scottish Parliament in 1999.Although Gaelic has benefited from an unprecedented programme of promotion and development in recent years, Gaelic issues stand at the margins in Scottish political life.In particular, the con

Plants adjust amplitude and duration of immune responses via different strategies Pepitas to maintain growth, development, and resistance to pathogens.Pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) play vital roles.Pattern recognition receptors, comprising a large number of receptor-like

Desalination plants have an important concern regarding controlling the permeate flow rate and pH during operability.This paper proposes the proportional integral derivative (PID) control design using modified Particle Swarm Optimization (PSO) techniques called autonomous groups PSO (AGPSO) in the two-input two-output (TITO) RO desalination plant t